Publications

Journal Articles

  1. McKiel LA, Ballantyne LL, Negri GL, Woodhouse KA and Fitzpatrick LE. (2023) MyD88-dependent Toll-like receptor 2 signaling modulates macrophage activation on lysate-adsorbed Teflon™ AF surfaces in an in vitro biomaterial host response model. Frontiers in Immunology, 14:1232586. doi: 10.3389/fimmu.2023.1232586
  2. Kaushal A, Zhang Y, Ballantyne LL, Fitzpatrick LE. (2022) “The extended effect of adsorbed damage-associated molecular patterns and Toll-like receptor 2 signaling on macrophage-material interactions,” Frontiers in Bioengineering and Biotechnology, 10:959512. doi: 10.3389/fbioe.2022.959512 
  3. McKiel LA, Woodhouse KA, Fitzpatrick LE. (2020) “A macrophage reporter cell assay to examine Toll-like receptor-mediated NF-kB/AP-1 signaling on adsorbed protein layers on polymeric surfaces,” Journal of Visualized Experiments, 155, e60317. doi:10.3791/60317
  4. McKiel LA, Woodhouse KA, Fitzpatrick LE. (2019) “Macrophage response to implanted materials via Toll-like receptor signaling,” Materials Research Society Communications. Published online.  doi:10.1557/mrc.2019.154
  5. McKiel LA, Fitzpatrick LE. (2018) “Toll-like receptor 2-dependent NF-κB/AP-1 activation by damage-associated molecular patterns adsorbed on polymeric surfaces,” ACS Biomaterials Science & Engineering, 4 (11):3792–3801. doi:10.1021/acsbiomaterials.8b00613
  6. Fitzpatrick LE*, McDevitt TC. (2015) Cell-derived matrices for tissue engineering and regenerative medicine applications. Biomaterials Science. 3(1): 12-24.  
  7. Fitzpatrick LE, Lisovsky A and Sefton MV. (2012) The expression of sonic hedgehog in diabetic wounds following treatment with poly(methacrylic acid-co-methyl methacrylate) beads. Biomaterials. 33(21): 5297-5307.
  8. Fitzpatrick SD, Fitzpatrick LE, Thakur A, Mazumder MAJ and Sheardown H. (2012) Temperature-sensitive polymers for drug delivery. Expert Review of Medical Devices. 9(4): 339-351.
  9. Fitzpatrick LE, Chan JWY and Sefton MV. (2011) On the mechanism of poly(methacrylic acid –co– methyl methacrylate)-induced angiogenesis: gene expression analysis of dTHP-1 cells. Biomaterials. 32(34): 8957-8967.
  10. Corstorphine L and Sefton MV. (2011) Effectiveness factor and diffusion limitations in collagen gel modules containing HepG2 cells. Journal of tissue engineering and regenerative medicine. 5(2): 119-129.
  11. Fitzpatrick SD, Jafar Mazumder MA, Lasowski F, Fitzpatrick LE, Sheardown H. (2010) PNIPAAm-grafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules. 11(9): 2261-2267.
  12. Chamberlain MD, Butler MJ, Ciucurel EC, Fitzpatrick LE, Khan OF, Leung BM, Lo C, Patel R, Velchinskaya A, Voice DN, Sefton MV. (2010) Fabrication of micro-tissues using modules of collagen gel containing cells. Journal of Visualized Experiments. 13;(46).

Recent Conference Presentations

  1. McKiel, LA*, Woodhouse, KA, and Fitzpatrick, LE. (2019) “Toll-like receptor 2-mediated macrophage activation by damage-associated molecular patterns on polymeric surfaces,” Annual General Meeting of the Canadian Biomaterials Society (National conference), Quebec City, QC (Oral). [Received 1 of 6 WBC 2016 Legacy Travel Awards to attend the conference]
  2. McKiel, LA, Comas, RP, Woodhouse, KA, and Fitzpatrick, LE*. (2019) “Immunomodulation of innate immune responses to biomaterials,” Annual General Meeting of the Canadian Biomaterials Society (National conference), Quebec City, QC (Oral).
  3. McKiel, LA*, Woodhouse, KA, and Fitzpatrick, LE. (2019) “Toll-like receptor activation by adsorbed damage-associated molecular patterns on polymeric surfaces,” Society for Biomaterials Annual Meeting and Exposition (International conference), Seattle, WA (Oral).
  4. McKiel, LA* and Fitzpatrick, LE. (2018) “Toll-like receptor 2-mediated NF-κB activation by damage-associated molecular patterns on polymeric surfaces,” Annual General Meeting of the Canadian Biomaterials Society (National conference), Victoria, BC (Oral). [Received 1 of 5 WBC 2016 Legacy Travel Awards to attend the conference] [Received 1 of 8 Best Oral Presentation Awards]
  5. McKiel, LA and Fitzpatrick, LE*. (2018) “Toll-like receptor 2-mediated inflammatory response to polymeric biomaterials,” Society for Biomaterials Annual Meeting and Exposition (International conference), Atlanta, GA (Oral).
  6. McKiel, LA and Fitzpatrick, LE*. (2018) “Toll-like receptor 2-mediated macrophage response to polymeric biomaterials,” MRS Spring Meeting (International conference), Phoenix, AZ (Oral).
  7. McKiel, LA* and Fitzpatrick, LE. (2017) “Toll-like receptor 2-dependent NF-κB/AP-1 activation by damage-associated molecular patterns adsorbed on polymeric surfaces,” Queen’s University Chemical Engineering Research Day (Institutional conference), Kingston, ON (Poster).
  8. McKiel, LA* and Fitzpatrick, LE. (2017) “Damage-associated molecular patterns in the adsorbed protein layer on biomaterial surfaces,” Q-Sense QCM-D Regional Technology Workshop (Provincial workshop), Hamilton, ON (Oral).
  9. McKiel, LA* and Fitzpatrick, LE. (2017) “Toll-like receptor 2-mediated NF-κB activation by damage-associated molecular patterns on biomaterial surfaces,” Annual General Meeting of the Canadian Biomaterials Society (National conference), Winnipeg. MB (Oral).
  10. McKiel, LA* and Fitzpatrick, LE. (2017) “Damage-associated molecular patterns in the adsorbed protein layer on biomaterial surfaces,” Annual Regenerative Medicine Symposium (National conference), Toronto, ON (Oral).
  11. McKiel, LA and Fitzpatrick, LE*. (2017) “Toll-like receptor 2-mediated NF-κB activation by damage-associated molecular patterns on biomaterial surfaces,” Society for Biomaterials Annual Meeting and Exposition (International conference), Minneapolis, MN (Oral).
  12. McKiel, LA* and Fitzpatrick, LE. (2016) “Damage-associated molecular patterns in the adsorbed protein layer on biomaterial surfaces,” Collaborative Biomedical Engineering Program Student Seminar Day (Departmental conference), Kingston, ON (Oral).
  13. McKiel, LA* and Fitzpatrick, LE. (2016) “Damage-associated molecular patterns in the adsorbed protein layer on biomaterial surfaces,” Queen’s University Chemical Engineering Research Day (Institutional conference), Kingston, ON (Poster).
  14. McKiel, LA* and Fitzpatrick, LE. (2016) “Damage-associated molecular patterns in the adsorbed protein layer on biomaterial surfaces,” World Biomaterials Congress (International conference), Montreal, QC (Oral).
  15. McKiel, LA, Antonyshyn JA, Chaplin, WT*, Fitzpatrick, LE. (2015) “An in vitro model of macrophage response and foreign body reaction to DAMPs,” Queen’s University Chemical Engineering Research Day (Institutional conference), Kingston, ON (Poster). [Best Undergraduate Poster Presentation]

Book Chapters

  1. Antonyshyn JA, Fitzpatrick LE* (2016) Stem cell and stem cell-derived molecular therapies to enhance dermal wound healing. In Singh A and Gaharwar AK (Eds.) Microscale Technologies for Cellular Engineering. Springer International Publishing (in press).
  2. Fitzpatrick LE#, Lisovsky A#, Ciucurel EC and Sefton MV (2014) Scaffold vascularization. In Migliaresi C and Motta A (Eds.) Scaffolds for tissue engineering: biological design, materials and fabrication. Pan Stanford Publishing.

(* corresponding or presenting author)
(# co-first author)